Notch Signaling: Endocytosis Makes Delta Signal Better
نویسندگان
چکیده
Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.
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ورودعنوان ژورنال:
- Current Biology
دوره 13 شماره
صفحات -
تاریخ انتشار 2003